一、基本信息
管清美，二級(jí)教授，博士，園藝學(xué)院院長(zhǎng)。
2002年畢業(yè)于西北農(nóng)林科技大學(xué)果樹(shù)專業(yè)，獲農(nóng)學(xué)學(xué)士學(xué)位；2005年畢業(yè)于西北農(nóng)林科技大學(xué)果樹(shù)專業(yè)，獲碩士學(xué)位；2013年畢業(yè)于美國(guó)馬里蘭大學(xué)植物學(xué)專業(yè)，獲博士學(xué)位。2005年-2008年在蚌埠學(xué)院任助教、講師；2013-2014年在美國(guó)馬里蘭大學(xué)進(jìn)行博士后研究工作；2014年到西北農(nóng)林科技大學(xué)園藝學(xué)院工作。國(guó)家青年人才項(xiàng)目、陜西省人才計(jì)劃入選者，任新疆蘋果產(chǎn)業(yè)技術(shù)體系副首席科學(xué)家、千陽(yáng)蘋果試驗(yàn)站首席科學(xué)家，兼任教育部科技委委員、教育部高等學(xué)校教指委委員，享受國(guó)務(wù)院特殊津貼。
主持國(guó)家自然科學(xué)基金杰出青年科學(xué)基金項(xiàng)目、優(yōu)秀青年科學(xué)基金項(xiàng)目、國(guó)家重點(diǎn)研發(fā)計(jì)劃等項(xiàng)目；榮獲全國(guó)巾幗建功標(biāo)兵、中國(guó)青年女科學(xué)家獎(jiǎng)、神農(nóng)青年英才、陜西省青年科技新星、陜西省五一巾幗標(biāo)兵、唐立新優(yōu)秀學(xué)者獎(jiǎng)等榮譽(yù)稱號(hào)；獲中國(guó)農(nóng)學(xué)會(huì)青年科技獎(jiǎng)、陜西省高等學(xué)校科學(xué)技術(shù)研究?jī)?yōu)秀成果獎(jiǎng)等。
二、研究方向
蘋果種質(zhì)資源抗性評(píng)價(jià)；蘋果耐非生物逆境基因挖掘及分子機(jī)制解析；蘋果基因組學(xué)；蘋果生物育種
三、科研項(xiàng)目
1.蘋果非生物脅迫關(guān)鍵調(diào)控基因的挖掘與利用，國(guó)家重點(diǎn)研發(fā)計(jì)劃“政府間國(guó)際科技創(chuàng)新合作”重點(diǎn)專項(xiàng)（2025-2028）
2.蘋果抗逆分子機(jī)制與分子育種，國(guó)家自然科學(xué)基金杰出青年科學(xué)基金（2023-2028）
3.MdHDG5在蘋果葉片蠟質(zhì)合成及抗旱中的功能和機(jī)制解析，國(guó)家自然科學(xué)基金面上項(xiàng)目（2022-2026）
4.蘋果現(xiàn)代育種技術(shù)研發(fā)與特色新種質(zhì)創(chuàng)制，陜西省重點(diǎn)研發(fā)計(jì)劃（2020-2024）
5.新疆蘋果產(chǎn)業(yè)技術(shù)體系（2024-2029）
6.蘋果GABA合成關(guān)鍵基因挖掘及作用機(jī)制研究，深圳市科學(xué)技術(shù)研究計(jì)劃（2022-2025）
7.蘋果成熟期調(diào)控關(guān)鍵基因挖掘及分子標(biāo)記開(kāi)發(fā)，深圳市科學(xué)技術(shù)研究計(jì)劃（2021-2024）
8.旱地果園“膜水肥一體化”肥水高效利用技術(shù)研究與示范，國(guó)家重點(diǎn)研發(fā)計(jì)劃（2022-2025）
9.果樹(shù)優(yōu)質(zhì)豐產(chǎn)的生理基礎(chǔ)與調(diào)控，國(guó)家重點(diǎn)研發(fā)計(jì)劃（2018-2022）
10.多年生園藝作物無(wú)性系變異和繁殖的基礎(chǔ)與調(diào)控，國(guó)家重點(diǎn)研發(fā)計(jì)劃（2018-2022）
11.蘋果MdARF-MdHYL1-MdMYB88/MdMYB124-MdSNF2調(diào)控網(wǎng)絡(luò)解析及抗寒功能鑒定，國(guó)家自然科學(xué)基金面上項(xiàng)目（2019-2022）
12.蘋果逆境分子生物學(xué)，國(guó)家自然科學(xué)基金優(yōu)秀青年科學(xué)基金（2017-2019）
13.蘋果耐旱的分子機(jī)制研究，國(guó)家青年人才計(jì)劃項(xiàng)目（2016-2018）
14.蘋果蛋白質(zhì)降解相關(guān)蛋白在干旱脅迫中的作用，西北農(nóng)林科技大學(xué)優(yōu)青培育專項(xiàng)（2015-2017）
15.秦冠蘋果一個(gè)鋅指蛋白(MdZFP1)在干旱脅迫下的功能分析，國(guó)家自然科學(xué)基金面上項(xiàng)目（2016-2019）
16.蘋果砧木耐旱關(guān)鍵小RNA的鑒定與分析，陜西省青年科技新星項(xiàng)目（2015-2017）
17.蘋果矮化自根砧抗逆的分子機(jī)理及抗性改良，西北農(nóng)林科技大學(xué)引進(jìn)人才科研啟動(dòng)項(xiàng)目（2014-2019）
四、主要學(xué)術(shù)論著
1.Wei Li#, Chong Chu#,*, Taikui Zhang#, Haochen Sun#, Shiyao Wang#, Zeyuan Liu#, Zijun Wang, Hui Li, Yuqi Li, Xingtan Zhang, Zhiqiang Geng, Youqing Wang, Yi Li, Hengtao Zhang, Weishu Fan, Yi Wang, Xuefeng Xu, Lailiang Cheng, Dehui Zhang, Yao Xiong, Huixia Li, Bowen Zhou, Qingmei Guan*, Cecilia H. Deng*, Yongming Han*, Hong Ma*, Zhenhai Han*. Pan-genome analysis reveals the evolution and diversity of Malus . Nature Genetics, 2025, 57, 1274–1286.
2.Fang Zhi#, Tianle Fan#, Jia Li, Shuo Zhang, Qian Qian, Arij Khalil, Chundong Niu, Kun Wang,Fengwang Ma, Xuewei Li, Qingmei Guan*. Engineering saline-alkali-tolerant apple rootstock by knocking down MdGH3 genes in M9-T337. Stress Biology, 2025, 5, 44
3.Tianle Fan#, Shufan Song#, Ningning Bian, Fang Zhi, Fengwang Ma, Qingmei Guan*, Xuewei Li*, Engineering saline-alkali-tolerant apple rootstocks by overexpressing MdHYL1 in M9-T337, Molecular Breeding, 2025, 45, 58
4.Nan Hou#, Jieqiang He#, Chana Bao#, Fang Zhi, Xiaoxia Shen, Yu Liu, Chaoshuo L1, Tianle Fan, Xinyue Yang, Baohua Chu, Gege Qin, Zeyuan Liu, Chuang Mei, Bin Tan, Jiancan Feng, Fengwang Ma, Mickael Malnoy*, Xuewei Li*,Qingmei Guan*.MdDSK2a-like-MdMTA module functions in apple cold response via regulating ROS detoxification and cell wall deposition. Advanced Science. 2025.
5.Yue Q, Xie Y, Yang X, Zhang Y, Li Z, Liu Y, Cheng P, Zhang R, Yu Y, Wang X, Liao L, Han Y, Zhao T, Li X, Zhang H, Ma F*, Guan Q*. An InDel variant in the promoter of the NAC transcription factor MdNAC18.1 plays a major role in apple fruit ripening. Plant Cell. 2024 Dec 23;37(1):koaf007.
6.Cao F, Qian Q, Li Z, Wang J, Liu Z, Zhang Z, Niu C, Xie Y, Ma F, Guan Q*. Natural variation in an HD-ZIP factor identifies its role in controlling apple leaf cuticular wax deposition. Developmental Cell. 2025 Mar 24;60(6):949-964.e6.
7.Song Y#, He J#, Guo J#, Xie Y, Ma Z, Liu Z, Niu C, Li X, Chu B, Tahir MM, Xu J, Ma F, Guan Q*. The chromatin remodeller MdRAD5B enhances drought tolerance by coupling MdLHP1-mediated H3K27me3 in apple. Plant Biotechnol J. 2024 Mar;22(3):617-634.
8.趙爽, 馬子清, 李雪薇, 李文強(qiáng), 管清美*. 不同果實(shí)生長(zhǎng)期虧缺灌溉對(duì)渭北蘋果生長(zhǎng)、品質(zhì)及水分利用效率的影響[J]. 西北植物學(xué)報(bào), 2024, 44 (03): 345-352.
9.趙爽, 馬子清, 李雪薇, 趙海亮, 管清美*. 不同時(shí)期水分脅迫對(duì)渭北蘋果品質(zhì)及水分利用效率的影響[J]. 西北園藝(果樹(shù)), 2024, (02): 60-63.
10.Xu J#, He J#,*, Hu B, Hou N, Guo J, Wang C, Li X, Li Z, Zhai J, Zhang T, Ma C, Ma F, Guan Q*. Global hypermethylation of the N6-methyladenosine RNA modification associated with apple heterografting. Plant Physiol. 2023 Nov 22;193(4):2513-2537.
11.Li X#, Ma Z, Song Y, Shen W, Yue Q, Khan A, Tahir MM, Wang X, Malnoy M, Ma F, Bus V, Zhou S*, Guan Q*. Insights into the molecular mechanisms underlying responses of apple trees to abiotic stresses. Hortic Res. 2023 Jul 27;10(8):uhad144.
12.Zhang D#, He J#, Cheng P, Zhang Y, Khan A, Wang S, Li Z, Zhao S, Zhan X, Ma F, Li X, Guan Q*. 4-methylumbelliferone (4-MU) enhances drought tolerance of apple by regulating rhizosphere microbial diversity and root architecture. Hortic Res. 2023 May 19;10(6):uhad099.
13.坎智勇, 張德輝*, 李中興, 余思思, 錢謙, 樊天樂(lè), 李雪薇, 馬鋒旺, 管清美*. 90個(gè)蘋果品種耐寒性評(píng)價(jià)和全基因組關(guān)聯(lián)分析[J]. 園藝學(xué)報(bào), 2023, 50 (05): 921-932.
14.Shen X#, Song Y#, Ping Y, He J, Xie Y, Ma F, Li X, Guan Q*. The RNA-binding protein MdHYL1 modulates cold tolerance and disease resistance in apple. Plant Physiol. 2023 Jul 3;192(3):2143-2160.
15.Shen X#, Ping Y, Bao C, Liu C, Tahir MM, Li X, Song Y, Xu W, Ma F, Guan Q*. Mdm-miR160-MdARF17-MdWRKY33 module mediates freezing tolerance in apple. Plant J. 2023 Apr;114(2):262-278.
16.He, J#; Guo, J#; Jiang, L; An, W; Ma, F; Guan, Q*; Niu, C*. Transcriptional Effects of Rootstock on Scion after Drought: A Case Study of Using MdGH3 RNAi as the Rootstock. Horticulturae 2022, 8 , 1212.
17.Cheng P#, Yue Q, Zhang Y, Zhao S, Khan A, Yang X, He J, Wang S, Shen W, Qian Q, Du W, Ma F, Zhang D*, Guan Q*. Application of γ-aminobutyric acid (GABA) improves fruit quality and rootstock drought tolerance in apple. J Plant Physiol. 2023 Jan;280:153890.
18.Bao C#, Qin G, Cao F, He J, Shen X, Chen P, Niu C, Zhang D, Ren T, Zhi F, Ma L, Ma F, Guan Q*. MdZAT5 regulates drought tolerance via mediating accumulation of drought-responsive miRNAs and mRNAs in apple. New Phytol. 2022 Dec;236(6):2131-2150.
19.Niu C#, Jiang L#, Cao F#, Liu C, Guo J, Zhang Z, Yue Q, Hou N, Liu Z, Li X, Tahir MM, He J, Li Z, Li C, Ma F,Guan Q*. Methylation of a MITE insertion in the MdRFNR1-1 promoter is positively associated with its allelic expression in apple in response to drought stress. Plant Cell. 2022 Sep 27;34(10):3983-4006.
20.儲(chǔ)寶華, 曹富國(guó), 卞寧寧, 錢謙, 李中興, 李雪薇, 劉澤遠(yuǎn), 馬鋒旺, 管清美*. 84個(gè)蘋果栽培品種對(duì)斑點(diǎn)落葉病的抗性評(píng)價(jià)和全基因組關(guān)聯(lián)分析[J]. 中國(guó)農(nóng)業(yè)科學(xué), 2022, 55 (18): 3613-3628.
21.Chen P#., Zhi F#., Li X.#, Shen W., Yan M., He J., Bao C., Fan T., Zhou S., Ma F., & Guan Q*. Zinc-finger protein MdBBX7/MdCOL9, a target of MdMIEL1 E3 ligase, confers drought tolerance in apple. Plant physiology, 2022 188(1), 540–559.
22.Li Z#, Wang L#, He J#, Li X#, Hou N, Guo J, Niu C, Li C, Liu S, Xu J, Xie Y, Zhang D, Shen X, Lu L, Geng D, Chen P, Jiang L, Wang L, Li H, Malnoy M, Deng C, Zou Y, Li C, Zhan X, Dong Y, Notaguchi M, Ma F*, Xu Q*,Guan Q*. Chromosome-scale reference genome provides insights into the genetic origin and grafting-mediated stress tolerance of Malus prunifolia. Plant Biotechnol J. 2022 Jun;20(6):1015-1017.
23.Li X#, Zhou S, Liu Z, Lu L, Dang H, Li H, Chu B, Chen P, Ma Z, Zhao S, Li Z, van Nocker S, Ma F*, Guan Q*. Fine-tuning of SUMOylation modulates drought tolerance of apple. Plant Biotechnol J. 2022 May;20(5):903-919.
24.Hou N#, Li C#, He J, Liu Y, Yu S, Malnoy M, Mobeen Tahir M, Xu L, Ma F, Guan Q*. MdMTA-mediated m6 A modification enhances drought tolerance by promoting mRNA stability and translation efficiency of genes involved in lignin deposition and oxidative stress. New Phytol. 2022 May;234(4):1294-1314.
25.趙爽, 馬子清, 張雨田, 程鵬達(dá), 李文強(qiáng), 管清美*. 陜西渭北地區(qū)不同時(shí)期控水對(duì)蘋果產(chǎn)量、品質(zhì)和水分利用效率的影響[J]. 北方園藝, 2022, (21): 38-43.
26.Jiang L#, Zhang D, Liu C, Shen W, He J, Yue Q, Niu C, Yang F, Li X, Shen X, Hou N, Chen P, Ma F, Guan Q*. MdGH3.6 is targeted by MdMYB94 and plays a negative role in apple water-deficit stress tolerance. Plant J. 2022 Mar;109(5):1271-1289.
27.Geng Da-li#, Li Lei, Yang Yu-sen, Ma Feng-wang, Guan Qing-mei*. Factors affecting hydraulic conductivity and methods to measure in plants,Journal of Integrative Agriculture,Volume 21, Issue 2,2022,Pages 310-315,ISSN 2095-3119.
28.Chen P#, Zhi F#, Li X#, Shen W, Yan M, He J, Bao C, Fan T, Zhou S, Ma F,Guan Q*. Zinc-finger protein MdBBX7/MdCOL9, a target of MdMIEL1 E3 ligase, confers drought tolerance in apple. Plant Physiol. 2022 Jan 20;188(1):540-559.
29.Jiang L#, Shen W#, Liu C, Tahir MM, Li X, Zhou S, Ma F, Guan Q*. Engineering drought-tolerant apple by knocking down six GH3 genes and potential application of transgenic apple as a rootstock. Hortic Res. 2022 May 26;9:uhac122.
30.Cao F#, Li Z#, Jiang L#, Liu C, Qian Q, Yang F, Ma F,Guan Q*. Genome-wide association study (GWAS) of leaf wax components of apple. Stress Biol. 2021 Nov 18;1(1):13.
31.Chen P#, Li Z#, Zhang D#, Shen W#, Xie Y, Zhang J, Jiang L, Li X, Shen X, Geng D, Wang L, Niu C, Bao C, Yan M, Li H, Li C, Yan Y, Zou Y, Micheletti D, Koot E, Ma F*, Guan Q*. Insights into the effect of human civilization on Malus evolution and domestication. Plant Biotechnol J. 2021 Nov;19(11):2206-2220.
32.Li C#, Hou N#, Fang N, He J, Ma Z, Ma F, Guan Q*, Li X*. Cold shock protein 3 plays a negative role in apple drought tolerance by regulating oxidative stress response. Plant Physiol Biochem. 2021 Nov;168:83-92.
33.Liu X#, Zhao C#, Gao Y, Xu Y, Wang S, Li C, Xie Y, Chen P, Yang P, Yuan L, Wang X, Huang L, Ma F, Feng H,Guan Q*. A multifaceted module of BRI1 ETHYLMETHANE SULFONATE SUPRESSOR1 (BES1)-MYB88 in growth and stress tolerance of apple. Plant Physiol. 2021 Apr 23;185(4):1903-1923.
34.Zhang D#, Yang K#, Kan Z, Dang H, Feng S, Yang Y, Li L, Hou N, Xu L, Wang X, Malnoy M, Ma F, Hao Y,Guan Q*. The regulatory module MdBT2-MdMYB88/MdMYB124-MdNRTs regulates nitrogen usage in apple. Plant Physiol. 2021 Apr 23;185(4):1924-1942.
35.Xie Y#, Bao C, Chen P, Cao F, Liu X, Geng D, Li Z, Li X, Hou N, Zhi F, Niu C, Zhou S, Zhan X, Ma F, Guan Q*. Abscisic acid homeostasis is mediated by feedback regulation of MdMYB88 and MdMYB124. J Exp Bot. 2021 Feb 2;72(2):592-607.
36.Baohua CHU#, Jia SUN#, Huan DANG, Ziqing MA, Shuang ZHAO, Qingmei GUAN*, Xuewei LI*.APPLE SUMO E3 LIGASE MDSIZ1 NEGATIVELY REGULATES DROUGHT TOLERANCE[J].Frontiers of Agricultural Science and Engineering,2021,(prepublish):0-.
37.Zhao C#, Liu X#, He J, Xie Y, Xu Y, Ma F, Guan Q*. Apple TIME FOR COFFEE contributes to freezing tolerance by promoting unsaturation of fatty acids. Plant Sci. 2021 Jan;302:110695. doi: 10.1016/j.plantsci.2020.110695.
38.Chen P#, Yan M, Li L, He J, Zhou S, Li Z, Niu C, Bao C, Zhi F, Ma F, Guan Q*. The apple DNA-binding one zinc-finger protein MdDof54 promotes drought resistance. Hortic Res. 2020 Dec 1;7(1):195.
39.Geng D#, Shen X#, Xie Y, Yang Y, Bian R, Gao Y, Li P, Sun L, Feng H, Ma F, Guan Q*. Regulation of phenylpropanoid biosynthesis by MdMYB88 and MdMYB124 contributes to pathogen and drought resistance in apple. Hortic Res. 2020 Jul 1;7:102.
40.Li X#, Chen P#, Xie Y, Yan Y, Wang L, Dang H, Zhang J, Xu L, Ma F, Guan Q*. Apple SERRATE negatively mediates drought resistance by regulating MdMYB88 and MdMYB124 and microRNA biogenesis. Hortic Res. 2020 Jul 1;7(1):98. doi: 10.1038/s41438-020-0320-6.
41.楊鋒, 劉晨, 姜麗娟, 管清美*. 蘋果屬植物抗旱性評(píng)價(jià)[J]. 西北農(nóng)林科技大學(xué)學(xué)報(bào)(自然科學(xué)版), 2020, 48 (08): 119-128.
42.Li, Xuewei#; Xie, Yinpeng#; Lu, Liyuan; Yan, Mingjia; Fang, Nan; Xu, Jidi; Wang, Liping; Yan, Yan; Zhao, Tao; van Nocker, Steve; Ma, Fengwang; Liang, Dong; Guan Qingmei*. Contribution of methylation regulation of MpDREB2A promoter to drought resistance of Mauls prunifolia[J].Plant and Soil,2019,441(1-2):15-32.
43.Geng Da-li#; Lu Li-yuan#; Yan Ming-jia; Shen Xiao-xia; Jiang Li-juan; Li Hai-yan; Wang Li-ping; Yan Yan; Xu Ji-di; Li Cui-ying; Yu Jian-tao; Ma Feng-wang;Guan Qing-mei*. Physiological and transcriptomic analyses of roots from Malus sieversii under drought stress. Journal of Integrative Agriculture, 2019, v.18(06):108-122.
44.Niu C#, Li H#, Jiang L, Yan M, Li C, Geng D, Xie Y, Yan Y, Shen X, Chen P, Dong J, Ma F, Guan Q*. Genome-wide identification of drought-responsive microRNAs in two sets of Malus from interspecific hybrid progenies. Hortic Res. 2019 Jun 8;6:75.
45.Geng D#, Chen P#, Shen X, Zhang Y, Li X, Jiang L, Xie Y, Niu C, Zhang J, Huang X, Ma F, Guan Q*. MdMYB88 and MdMYB124 Enhance Drought Tolerance by Modulating Root Vessels and Cell Walls in Apple. Plant Physiol. 2018 Nov;178(3):1296-1309.
46.Xie Y#, Chen P#, Yan Y, Bao C, Li X, Wang L, Shen X, Li H, Liu X, Niu C, Zhu C, Fang N, Shao Y, Zhao T, Yu J, Zhu J, Xu L, van Nocker S, Ma F, Guan Q*. An atypical R2R3 MYB transcription factor increases cold hardiness by CBF-dependent and CBF-independent pathways in apple. New Phytol. 2018 Apr;218(1):201-218.
47.王麗平, 姜麗娟, 馬鋒旺, 管清美*. 蘋果HYL1基因在干旱中的表達(dá)與功能分析[J]. 西北農(nóng)林科技大學(xué)學(xué)報(bào)(自然科學(xué)版), 2018, 46 (07): 109-116.
48.Xu J#, Zhou S, Gong X, Song Y, van Nocker S, Ma F*,Guan Q*. Single-base methylome analysis reveals dynamic epigenomic differences associated with water deficit in apple. Plant Biotechnol J. 2018 Feb;16(2):672-687.
49.李海燕, 耿達(dá)立, 牛春東, 李翠英, 管清美*. 蘋果砧木富平楸子和G935根系抗旱性評(píng)估[J]. 西北農(nóng)林科技大學(xué)學(xué)報(bào)(自然科學(xué)版), 2018, 46 (05): 118-124.
五、獲批專利
1. 管清美、程鵬達(dá)、張德輝、岳倩宇、趙爽、張雨田、楊欣玥、毛秀山。提高蘋果矮化砧木水分利用率和果實(shí)品質(zhì)氨基酸施用方法。狀態(tài)：已授權(quán)。專利號(hào)：ZL 202210158183.4
2. 管清美、張德輝、程鵬達(dá)、張雨田、趙爽。4-甲基傘形酮在提高植物抗干旱上的用途。狀態(tài)：已授權(quán)。專利號(hào)：ZL2022111466082.5。
3. 管清美、申小霞、毛秀山、平怡坤、李雪薇、樊天樂(lè)、張子桐。促進(jìn)砧木根系發(fā)育及抗旱的可移動(dòng)miRNA及鑒定方法。狀態(tài)：已授權(quán)。專利號(hào)：ZL202120550698.4。
4. 管清美、牛春東、張子桐、曹富國(guó)、錢謙、劉澤遠(yuǎn)、李中興、姜麗娟。一種應(yīng)用于蘋果轉(zhuǎn)基因的藥劑濃度篩選方法。狀態(tài)：已授權(quán)。專利號(hào)：ZL202111250967.1
5. 管清美、申文赟、毛秀山、李雪薇、陳鵬翔、李中興、謝銀鵬。一種調(diào)控蘋果果形和大小的基因及應(yīng)用。狀態(tài)：已授權(quán)。專利號(hào)：ZL202110387552.2
6. 管清美、劉小芳、謝銀鵬、趙才德、徐垚、王淑瑾、張琬婷、張丹妮。轉(zhuǎn)錄因子在增加蘋果枝條開(kāi)張角度中的應(yīng)用。狀態(tài)：已授權(quán)。專利號(hào)：ZL201911236458.6
六、聯(lián)系方式
通訊地址：陜西楊凌邰城路3號(hào) 西北農(nóng)林科技大學(xué)園藝學(xué)院221室
郵編：712100
電話：029-87082648
Email: qguan@nwafu.edu.cn
