1.基本信息
劉長(zhǎng)海，1987年2月生，山東費(fèi)縣人，教授，博士生導(dǎo)師。2009年本科畢業(yè)于青島農(nóng)業(yè)大學(xué)園藝專業(yè)；2012年碩士畢業(yè)于西北農(nóng)林科技大學(xué)果樹(shù)學(xué)專業(yè)；2016年博士畢業(yè)于丹麥哥本哈根大學(xué)植物病理學(xué)專業(yè)。2016年7月到西北農(nóng)林科技大學(xué)工作至今。
2.研究方向
蘋果-病原真菌互作、蘋果抗/感真菌病害基因挖掘、蘋果抗病性調(diào)控等研究。
（1）蘋果樹(shù)腐爛病菌、炭疽葉枯病菌、鐮孢菌等效應(yīng)因子致病機(jī)理
（2）蘋果抗/感真菌病害關(guān)鍵基因挖掘與作用機(jī)制解析
（3）蘋果抗病調(diào)控技術(shù)及種質(zhì)創(chuàng)新
3.開(kāi)設(shè)課程
講授本科生“園藝植物生物技術(shù)”、“果樹(shù)生理學(xué)”、“園藝植物栽培學(xué)總論”、“果樹(shù)栽培學(xué)總論”等理論教學(xué)和“園田操作技能訓(xùn)練”、“果樹(shù)夏季管理”、“科技市場(chǎng)調(diào)查”等實(shí)踐課程；講授研究生“現(xiàn)代果樹(shù)科學(xué)進(jìn)展”和全英文課程“園藝植物逆境功能基因組學(xué)”。
4.科研項(xiàng)目
（1）自噬參與ABA誘發(fā)腐爛病抗性因子MdLYK10降解的分子機(jī)制解析，國(guó)家自然科學(xué)基金面上項(xiàng)目，32172529，2022.1-2025.12，58萬(wàn)，主持
（2）蘋果抗逆矮化砧木選育，陜西省科技重大專項(xiàng)，2020zdzx03-01-01，2019.8-2023.12，145萬(wàn)，子課題主持
（3）果樹(shù)應(yīng)答真菌病害的分子機(jī)制，國(guó)家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目，2018YFD1000300，2018.10-2022.09，46萬(wàn)，子課題主持
（4）RNA結(jié)合蛋白MdYTP2在蘋果抗褐斑病應(yīng)答中的功能和作用機(jī)制解析，國(guó)家自然科學(xué)基金青年項(xiàng)目，31701897，2018.01-2020.12，25萬(wàn)，主持
（5）蘋果PI4Kγ2在抗腐爛病中的功能及其mRNA降解機(jī)制解析，中國(guó)博士后科學(xué)基金第11批特別資助, 2018T111108，2018.03-2020.02，15萬(wàn)，主持
（6）蘋果褐斑病感病基因MdYTP2的表達(dá)調(diào)控機(jī)制解析，中國(guó)博士后科學(xué)基金第61批面上一等資助，2017M610657，2017.03-2019.03，8萬(wàn)，主持
（7）蘋果MhYTP2與MhARD4互作負(fù)調(diào)控褐斑病抗性機(jī)理研究，陜西省自然科學(xué)基礎(chǔ)研究計(jì)劃項(xiàng)目，2018JQ3008，2018.011-2019.12，3萬(wàn)，主持
（8）楊凌示范區(qū)科技計(jì)劃項(xiàng)目，2017.11-2019.10，10萬(wàn)，主持
（9）中央高校基本科研業(yè)務(wù)費(fèi)，2017.05-2019.04，10萬(wàn)，主持
（10）西北農(nóng)林科技大學(xué)博士科研啟動(dòng)項(xiàng)目，2016.07-2019.06，20萬(wàn)，主持
5.發(fā)表論文 (#共同第一作者，*共同通訊作者)
(26) Tingting Pei, Dongshan Niu, Yongxin Ma, Minghui Zhan, Jie Deng, Pengmin Li, Fengwang Ma*, Changhai Liu*. 2024. MdWRKY71 promotes the susceptibility of apple to Glomerella leaf spot by controlling salicylic acid degradation. Molecular Plant Pathology , 25, e13457.
(25) Tingting Pei#, Minghui Zhan#, Dongshan Niu, Yuerong Liu, Jie Deng, Yuanyuan Jing, Pengmin Li*, Changhai Liu*, Fengwang Ma*. 2024. CERK1 compromises Fusarium solani resistance by reducing jasmonate level and undergoes a negative feedback regulation via the MMK2-WRKY71 module in apple. Plant, Cell & Environment , 47, 2491–2509.
(24) Runmin Che#, Changhai Liu#, Qi Wang, Wenyan Tu, Ping Wang, Chao Li, Xiaoqing Gong, Ke Mao, Hao Feng, Lili Huang, Pengmin Li & Fengwang Ma*. 2023. The Valsa Mali effector Vm1G-1794 protects the aggregated MdEF-Tu from autophagic degradation to promote infection in apple. Autophagy . 19:6, 1745-1763.
(23) Tianli Guo#, Changhai Liu#, Fanxin Meng, Liu Hu, Xiaomin Fu, Zehua Yang, Na Wang, Qi Jiang, Xiuzhi Zhang, Fengwang Ma*. 2022. The m6A reader MhYTP2 regulates MdMLO19 mRNA stability and antioxidant genes translation efficiency conferring powdery mildew resistance in apple. Plant Biotechnology Journal , 20(3): 511-525.
(22) Yubo Sun#, Danyan Luo#, Yuerong Liu, Wenyan Tu, Runmin Che, Hao Feng, Lili Huang, Fengwang Ma*, Changhai Liu*. 2024. Valsa mali effector Vm_04797 interacts with the adaptor protein MdAP-2β to manipulate host autophagy. Plant Physiology. 195:502–517.
(21) Runmin Che, Yuerong Liu, Shengqi Yan, Chao Yang, Yubo Sun, Changhai Liu*,Fengwang Ma*. 2023. Elongation factor MdEF-Tu coordinates with heat shock protein MdHsp70 to enhance apple thermotolerance. The Plant Journal. doi: 10.1111/tpj.16561.
(20) Yuanyuan Jing, Tingting Pei, Chunrong Li, Duanni Wang, Qi Wang, Yijia Chen, Pengmin Li, Changhai Liu*, Fengwang Ma*. 2023. Overexpression of the FERONIA receptor kinase MdMRLK2 enhances apple cold tolerance. The Plant Journal . 115: 236-252.
(19) Tianli Guo, Zehua Yang, Ru Bao, Xiaomin Fu, Na Wang, Changhai Liu*, Fengwang Ma*. 2023. The m6A reader MhYTP2 regulates the stability of its target mRNAs contributing to low nitrogen tolerance in apple ( Malus domestica ). Horticulture Research . 10(6), doi.org/10.1093/hr/uhad094.
(18) Tianli Guo, Ru Bao, Zehua Yang, Xiaomin Fu, Liu Hu, Na Wang, Changhai Liu*, Fengwang Ma*. 2023. The m6A reader MhYTP2 negatively modulates apple Glomerella leaf spot resistance by binding to and degrading MdRGA2L mRNA. Molecular Plant Pathology . doi.org/10.1111/mpp.13370.
(17) Yuanyuan Jing, Minghui Zhan, Chunrong Li, Tingting Pei, Qi Wang, Pengmin Li*, Fengwang Ma*, Changhai Liu*. 2022. The apple FERONIA receptor-like kinase MdMRLK2 negatively regulates Valsa canker resistance by suppressing defense responses and hypersensitive reaction. Molecular Plant Pathology , doi.org/10.1111/mpp.13218.
(16) Qian Wang, Dong Huang, Wenyan Tu, Fengwang Ma*, Changhai Liu*. 2022. Overexpression of auxin/indole-3-acetic acid gene MdIAA24 enhances Glomerella leaf spot resistance in apple ( Malus domestica ). Horticultural Plant Journal, doi.org/10.1016/j.hpj.2022.12.011.
(15) Qian Wang#, Changhai Liu#, Dong Huang, Qinglong Dong, van Nocker S, Pengmin Li*, Fengwang Ma*. 2020. Physiological evaluation of nitrogen use efficiency of different apple cultivars under various nitrogen and water supply conditions. Journal of Integrative Agriculture , 19(3): 709-720.
(14) Yuerong Liu#, Lulu Yang#, Danyan Luo, Ziyan Mou, Changhai Liu*, Fengwang Ma*. 2024. The HD-Zip I transcription factor MdHB-7 negatively regulates Valsa canker resistance in apple ( Malus domestica ). Scientia Horticulturae. 324,112623.
(13) Chunrong Li#, Yuanyuan Jing#, Liang Cheng#, Zeguang Si, Ziyan Mou, Dongshan Niu, Fengwang Ma#, Changhai Liu#. 2023. The antifungal activity of trans-cinnamic acid and its priming effect in apple in response to Valsa mali. Plant Pathology. DOI: 10.1111/ppa.13786.
(12) Qian Wang, Dong Huang, Dongshan Niu, Jie Deng, Fengwang Ma*, Changhai Liu*. 2021.Overexpression of auxin response gene MdIAA24 enhanced cadmium tolerance in apple ( Malus domestica ). Ecotoxicology and Environmental Safety , 225: 112734.
(11) Tingting Sun#, Tingting Pei#, Lulu Yang, Zhijun Zhang, Mingjun Li, Yuerong Liu, Fengwang Ma*, Changhai Liu*. 2021. Exogenous application of xanthine and uric acid and nucleobase-ascorbate transporter MdNAT7 expression regulate salinity tolerance in apple. BMC Plant Biology , 21:52.
(10) Tianli Guo, Xiuzhi Zhang, Yuxing Li, Chenlu Liu, Na Wang, Qi Jiang, Junyao Wu, Fengwang Ma*, Changhai Liu*. 2020. Overexpression of MdARD4 accelerates fruit ripening and increases cold hardiness in tomato. International Journal of Molecular Science , 21, 6182; doi: 10.3390/ijms21176182.
(9) Changhai Liu, Tianli Guo, Na Wang, Qian Wang, Yangchun Xue, Minghui Zhan, Qingmei Guan, Fengwang Ma*. 2019. Overexpression of MhYTP2 enhances apple water-use efficiency by activating ABA and ethylene signaling. Environmental and Experimental Botany , 157: 260-268.
(8) Tianli Guo, Na Wang, Yangchun Xue, Qingmei Guan, Steven van Nocker, Changhai Liu*, Fengwang Ma*. 2019. Overexpression of the RNA binding protein MhYTP1 in transgenic apple enhances drought tolerance and WUE by improving ABA level under drought condition. Plant Science , 280: 397-407.
(7) Qian Wang#, Changhai Liu#, Dong Huang, Qinglong Dong, Pengmin Li*, Fengwang Ma*. 2019. High-efficient utilization and uptake of N contribute to higher NUE of ‘Qinguan’ apple under drought and N-deficient conditions compared with ‘Honeycrisp’. Tree Physiology , 11: 1880-1895.
(6) Qian Wang#, Changhai Liu#, Qinglong Dong, Dong Huang, Cuiying Li, Pengmin Li*, Fengwang Ma*. 2018. Genome-wide identification and analysis of apple NITRATE TRANSPORTER 1/PEPTIDE TRANSPORTER family (NPF) genes reveals MdNPF6.5 confers high capacity for nitrogen uptake under low-nitrogen conditions. International Journal of Molecular Sciences , 19, 276.
(5) Chao Li,?Qi Zhao,?Tengteng Gao,?Hongying Wang,?Zhijun?Zhang,?Bowen Liang,?Zhiwei Wei, Changhai Liu*,?Fengwang Ma*. 2018. The mitigation effects of exogenous melatonin on replant disease in apple. Journal of Pineal Research . 65(4). e12523.
(4) Tingting Sun, Tingting Pei, Zhijun Zhang, Mingjun Li, Linlin Huang, Cuiying Li, Xueyan Shi, Minghui Zhan, Xiaoyu Cao, Fengwang Ma*, Changhai Liu*. 2018. Activated expression of PHT genes contributes to osmotic stress resistance under low phosphorus levels in Malus . Journal of the American Society for Horticultural Science . 143(6): 436-445.
(3) Changhai Liu, Carsten Pedersen, Torsten Schultz-Larsen, Aguilar BG, Madriz-Orderana K, Hovmoller SM, Hans Thordal-Christensen*. 2016. The stripe rust fungal effector PEC6 suppresses pattern-triggered immunity in a host species-independent manner and interacts with adenosine kinases. New Phytologist . doi.org/10.1111/nph.14034
(2) Changhai Liu, Chao Li, Dong Liang, FengwangMa*, Shuncai Wang, Ping Wang, Rongchao Wang. 2013. Aquaporin expression in response to water-deficit stress in two Malus species: relationship with physiological status and drought tolerance. Plant Growth Regulation , 70: 187-197.
(1) Changhai Liu, Chao Li, Dong Liang, Zhiwei Wei, Shasha Zhou, Rongchao Wang, FengwangMa*. 2012. Differential expression of ion transporters and aquaporins in leaves may contribute to different salt tolerance in Malus species. Plant Physiology and Biochemistry , 58: 159-165. doi: 10.1111/nph.14034.
6. 聯(lián)系方式
通訊地址：陜西省楊凌示范區(qū)邰城路3號(hào)西北農(nóng)林科技大學(xué)園藝學(xué)院
郵編：712100
E-mail: chliu@nwafu.edu.cn; Lch198702@163.com;
